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Harvesting the Ancestral Life Power of Olive  

  • Olives and Olive Oil are the centerpiece of the Mediterranean diet with clinically proven health benefits
  • Olives are one of the richest source of monounsaturated fatty acids and polyphenols in nature
  • Olive oil, unfortunately, contains 1% or less of the total antioxidant content of the olive
  • Majority of active polyphenols, responsible for the antioxidant activity, are lost into olive vegetation water (olive juice), which is disposed in the production of olive oil as wastewater.
  • Olives and Olive Oil are the centerpiece of the Mediterranean diet with clinically proven health benefits

No industrial process had been developed for the recovery of this unique class of antioxidants from olive wastewater before 2001.

Profile of Hidrox®  

  • Multiple lines of converging evidence link polyphenols, particularly hydroxytyrosol and HIDROX®, to improved clinical outcomes.
  • In human and animal studies, hydroxytyrosol and HIDROX® have been shown to induce significant therapeutic effects on the cardiovascular system, improve the quality of life of patients with osteoporosis, and reduce markers of inflammation. These findings have all been reported in peer-reviewed, internationally-recognised academic journals.
  • Hydroxytyrosol is well absorbed following oral administration, and rapidly reaches high levels in the blood.
  • Hydroxytyrosol and HIDROX® have strong safety profiles and are not associated with major adverse events. Patients receiving HIDROX® are likely to have a strong level of adherence to the supplement.

HIDROX® is CreAgri's trademarked name for hydroxytyrosol. Hydroxytyrosol is a potent and protective polyphenol found mainly in olives. Polyphenols are scientifically recognized for their powerful antioxidant capacity, and are considered to play an important role in extra virgin olive oil's health benefits. Independent laboratory analyses have demonstrated that hydroxytyrosol is the most potent antioxidant yet discovered. Olive polyphenols are abundant in olive water, but only present in extra virgin olive oil in small amounts. CreAgri uses a proprietary process created by Dr. Roberto Crea, founder of CreAgri.

Effects of HIDROX® and hydroxytyrosol on cholesterol  

Numerous human and animal studies have shown that polyphenols, particularly hydroxytyrosol and HIDROX®, can safely and effectively improve blood cholesterol profiles and prevent the formation of plaques within the arteries (atherosclerosis). These effects could help reduce the risk of myocardial infarction (heart attack) and stroke.

In a 6-month clinical trial of HIDROX® in patients with hyperlipidemia, twice daily administration of HIDROX® was associated with a significant reduction in V-LDL cholesterol levels in trial participants (Bitler et al., 20xx). V-LDL cholesterol contains the highest amount of triglyceride fat of all cholesterol subtypes; high levels of V-LDL cholesterol can significantly raise the risk of coronary artery disease and myocardial infarction. By reducing V-LDL levels in patients, HIDROX® could significantly reduce the risk of cardiovascular mortality.

In the EUROLIVE clinical study (a major, multicentre trial conducted in five European countries), 200 healthy male volunteers received 25 ml of olive oil containing either low, medium, or high concentrations of polyphenols once a day for three weeks. High polyphenol olive oil resulted in significantly raised levels of HDL cholesterol (Covas et al., 2006). HDL levels in study participants increased by 0.045 mmol/L; previously in a separate study, a 0.026 mmol/L increase in HDL was associated with a 2-3 % decrease in heart disease risk (Gordon et al., 1989). Polyphenol-rich olive oil therefore has the potential to significantly reduce the incidence of cardiovascular mortality.

High polyphenol olive oil also invoked a significant reduction in the levels of oxidated LDL cholesterol; numerous studies have now linked oxidized LDL to the development of obstructive plaques within arteries. Oxidized LDL can enter arteries and form plaques which may constrict the flow of blood to the heart, invoke substantial tissue damage, and increase the risk of myocardial infarction and sudden cardiac death. Oxidation of LDL allows it to enter the wall of the artery where it can form plaques to obstruct blood flow. By significantly reducing levels of oxidized LDL in the body, high polyphenol content olive oil may be able to exert substantial cardioprotective effects.

Isolated hydroxytyrosol has been shown to have a direct, beneficial effect on the formation of atherosclerotic plaques in an animal model. Administration of hydroxytyrosol to rabbits for one month resulted in a prominent reduction of the size of plaques formed in the aorta; this effect of hydroxytyrosol is of significant clinical importance and could help reduce the risk of myocardial infarction and sudden death. Additionally, hydroxytyrosol resulted in a 50 % reduction in total cholesterol levels; these multiple beneficial effects of hydroxytyrosol were directly linked to the agent’s powerful antioxidant effects (Gonzalez-Santiago et al., 2006).

Hydroxytyrosol prevents the formation of potentially lethal blood clots  

Blood clots (thromboses) are an important cause of myocardial infarction and sudden cardiac death. A clinical study conducted in a high risk patient population demonstrated that hydroxytyrosol could reduce an important biomarker of thrombosis, suggesting that it could exert important anticoagulant effects.

In a clinical study of hydroxytyrosol’s effects in type I diabetic patients, 12.5-25 mg of a hydroxytyrosol solution was administered once daily for 4 days. Hydroxytyrosol produced a significant decrease in plasma levels of thromboxane B2 (a metabolite of thromboxane A2, which is responsible for platelet aggregation and the formation of blood clots). This finding indicates that hydroxytyrosol may reduce the risk of thrombosis and myocardial infarction. Importantly, these beneficial effects occurred within a very short time frame (4 days) (Leger et al., 2005).

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